Open Access Research article

Proteomic profiling and functional characterization of early and late shoulder osteoarthritis

John Paul Wanner1, Roopashree Subbaiah1, Yelenna Skomorovska-Prokvolit4, Yousef Shishani1, Eric Boilard2, Sujatha Mohan3, Robert Gillespie1, Masaru Miyagi4 and Reuben Gobezie15*

Author Affiliations

1 Department of Orthopaedics, Case Western Reserve University, School of Medicine, Cleveland, OH, USA

2 Centre de Recherche en Rhumatologie et Immunologie, Centre de Recherche du Centre Hospitalier Universitaire de Québec, Faculté de Médecine de l’Université Laval, Québec, QC G1V 4G2, Canada

3 Laboratory for Integrated Bioinformatics, RIKEN Center for Integrative Medical Sciences (IMS-RCAI), RIKEN Yokohama Institute, Kanagawa, 230 0045, Japan

4 Case Center for Proteomics and Bioinformatics, Case Western Reserve University, School of Medicine, Cleveland, OH, USA

5 Cleveland Shoulder Institute, University Hospitals of Cleveland, 5885 Landerbrook Drive, Monarch Center, Mayfield Heights, OH, 44121, USA

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Arthritis Research & Therapy 2013, 15:R180  doi:10.1186/ar4369

Published: 6 November 2013

Additional files

Additional file 1: Table S1:

Information contained in this table is provided under two separate headers. The first header that starts with Protein details provides information about the protein. The second header that begins with Peptide details provides information about the peptide identified within Mascot.

Format: XLSX Size: 2.5MB Download file

Open Data

Additional file 2: Table S2:

This table lists the proteins quantified in the five early-stage osteoarthritis (OA) sets versus control experiments and the four late-stage OA versus control experiments.

Format: XLSX Size: 173KB Download file

Open Data

Additional file 3: Table S3:

This table lists the proteins found across the early- and late-stage osteoarthritis (OA) samples with statistical analyses as well.

Format: XLSX Size: 52KB Download file

Open Data

Additional file 4: Table S4:

This table displays the fold changes of proteins from patients with early osteoarthritis (OA), bound to the high capacity multiple affinity removal spin cartridge.

Format: XLSX Size: 14KB Download file

Open Data

Additional file 5: Table S5:

This table displays the differentially expressed proteins in early-and late-stage osteoarthritis (OA) samples with fold changes ≥1.5 and ≤ -1.5.

Format: XLSX Size: 20KB Download file

Open Data