Disease severity in sialoadhesin (Sn)+/+ and Sn−/− NZBWF1 mice. (A) Disease onset and progression was determined by measurement of proteinuria in each of the indicated genotypes; n = 7, 10 and 10 mice per group for Sn+/+, Sn+/− and Sn−/− respectively. (B) Serum immunoassays of IgM and IgG anti-dsDNA at 18, 22 and 26 weeks of age. (C) Light microscopy-based scoring of disease severity in glomerular, tubulointerstitial and perivascular compartments in 28-week old mice; n = 6 mice per group.
Kidder et al. Arthritis Research & Therapy 2013 15:R175 doi:10.1186/ar4364