Transcriptional landscapes of emerging autoimmunity: transient aberrations in the targeted tissue’s extracellular milieu precede immune responses in Sjögren’s syndrome
1 Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Laboratory Building, Jonas Liesvei 65, 5021 Bergen, Norway
2 Department of Infectious Diseases and Pathology, College of Veterinary Medicine, University of Florida, 2015 S.W. 16th Avenue, Gainesville, FL 32610, USA
3 Computational Biology Unit, Uni-Computing, UniResearch AS, Thormøhlensgate 55, 5008 Bergen, Norway
4 Department of Rheumatology, Haukeland University Hospital, Jonas Liesvei 65, 5021 Bergen, Norway
Arthritis Research & Therapy 2013, 15:R174 doi:10.1186/ar4362Published: 31 October 2013
Additional file 1:
Figure S1. Verification of the microarray data. Figure S2. Stabilization of the subclinical disease state between 8 and 12 weeks of age. Figures S3 to S7. Contributions of genes located in susceptibility regions Aec1 and Aec2 to enrichments and depletions associated with transition from pre- to subclinical Sjögren’s syndrome (SS) and to onset of overt SS, respectively. Figure S8. Interactome model based on the leading edge members associated with enrichments in the transcriptional landscape of the extracellular milieu during transition from pre- to subclinical Sjögren’s syndrome between 4 and 8 weeks of age.
Format: PDF Size: 764KB Download file
This file can be viewed with: Adobe Acrobat Reader
Additional file 2:
All node parameters, LE genes and LE genes located in susceptibility regions Aec1 and Aec2 in tabular form.
Format: XLS Size: 144KB Download file
This file can be viewed with: Microsoft Excel Viewer