Email updates

Keep up to date with the latest news and content from Arthritis Research & Therapy and BioMed Central.

Open Access Research article

Transcriptional landscapes of emerging autoimmunity: transient aberrations in the targeted tissue’s extracellular milieu precede immune responses in Sjögren’s syndrome

Nicolas Delaleu1*, Cuong Q Nguyen2, Kidane M Tekle3, Roland Jonsson14 and Ammon B Peck2

Author Affiliations

1 Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Laboratory Building, Jonas Liesvei 65, 5021 Bergen, Norway

2 Department of Infectious Diseases and Pathology, College of Veterinary Medicine, University of Florida, 2015 S.W. 16th Avenue, Gainesville, FL 32610, USA

3 Computational Biology Unit, Uni-Computing, UniResearch AS, Thormøhlensgate 55, 5008 Bergen, Norway

4 Department of Rheumatology, Haukeland University Hospital, Jonas Liesvei 65, 5021 Bergen, Norway

For all author emails, please log on.

Arthritis Research & Therapy 2013, 15:R174  doi:10.1186/ar4362

Published: 31 October 2013

Additional files

Additional file 1:

Figure S1. Verification of the microarray data. Figure S2. Stabilization of the subclinical disease state between 8 and 12 weeks of age. Figures S3 to S7. Contributions of genes located in susceptibility regions Aec1 and Aec2 to enrichments and depletions associated with transition from pre- to subclinical Sjögren’s syndrome (SS) and to onset of overt SS, respectively. Figure S8. Interactome model based on the leading edge members associated with enrichments in the transcriptional landscape of the extracellular milieu during transition from pre- to subclinical Sjögren’s syndrome between 4 and 8 weeks of age.

Format: PDF Size: 764KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data

Additional file 2:

All node parameters, LE genes and LE genes located in susceptibility regions Aec1 and Aec2 in tabular form.

Format: XLS Size: 144KB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data

Additional file 3:

The networks displayed in Figures 3-7 as infinitely scalable and electronically searchable vector graphics.

Format: PDF Size: 121KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data