Relationship between interleukin 17 receptor occupancy levels and serum brodalumab concentrations. Each symbol represents an individual sample collected during the study for all patients receiving brodalumab. Circles indicate samples with detectable pharmacokinetic (PK) levels of serum brodalumab, and triangles indicate samples below the level of quantitation (LOQ).
Martin et al. Arthritis Research & Therapy 2013 15:R164 doi:10.1186/ar4347