Expression of LL37, IFNα and BDCA2 in anti-neutrophil cytoplasmic antibody-associated vasculitis patients with crescentic glomerulonephritis. (A), (B) Representative images showing the co-localisation of LL37 (red) and BDCA2, a marker of plasmacytoid dendritic cells (green), in the glomeruli of frozen renal biopsy sections after immunofluorescence staining. (C) Co-localisation of interferon alpha (IFNα; red) and LL37 (green) in renal biopsy sections from anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) patients with crescentic glomerulonephritis (GN). (D) Co-localisation of IFNα (red) and LL37 (green) in renal biopsy sections from AAV patients without crescentic GN.
Zhang et al. Arthritis Research & Therapy 2013 15:R161 doi:10.1186/ar4344