Number of anticitrullinated fibrinogen antibodies in pre–rheumatoid arthritis cases by years prior to rheumatoid arthritis diagnosis. Number of anticitrullinated fibrinogen antibodies in subgroups of cases diagnosed (a) 10 years or more (b) 5 years to less than 10 years and (c) less than 5 years before diagnosis of rheumatoid arthritis (RA) in the Nurses’ Health Study and Nurses’ Health Study II. ACPA: anticitrullinated peptide antibody.
Arkema et al. Arthritis Research & Therapy 2013 15:R159 doi:10.1186/ar4342