Open Access Highly Accessed Research article

Anti-citrullinated peptide autoantibodies, human leukocyte antigen shared epitope and risk of future rheumatoid arthritis: a nested case–control study

Elizabeth V Arkema12*, Barbara L Goldstein1, William Robinson3, Jeremy Sokolove3, Catriona A Wagner3, Susan Malspeis1, Bernard Rosner24, Francine Grodstein25, Elizabeth W Karlson1 and Karen H Costenbader1

Author Affiliations

1 Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA

2 Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA

3 Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine CCSR, 269 Campus Drive, Stanford, CA 94305, USA

4 Department of Biostatistics, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA

5 Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA

For all author emails, please log on.

Arthritis Research & Therapy 2013, 15:R159  doi:10.1186/ar4342

Published: 23 October 2013

Additional files

Additional file 1: Table S1:

Anti-Citrullinated Peptide Autoantibodies in Women and Risk of Future Rheumatoid Arthritis in NHS and NHSII.

Format: DOC Size: 55KB Download file

This file can be viewed with: Microsoft Word Viewer

Open Data

Additional file 2: Table S2:

Number of positive anti-citrullinated peptide autoantibodies in preclinical RA cases and their matched controls by time prior to RA onset (< 5 years, 5–10 years, ≥10 years) NHS and NHSII.

Format: DOC Size: 14KB Download file

This file can be viewed with: Microsoft Word Viewer

Open Data

Additional file 3: Table S3:

Characteristics of preclinical RA cases with blood drawn less than 5 years before diagnosis (N = 64) in NHS and NHSII.

Format: DOC Size: 14KB Download file

This file can be viewed with: Microsoft Word Viewer

Open Data