Table 2

Concordance between HLA-B27 and tagging SNP rs4349859 and rs116488202 genotypes in New Zealand controls and ankylosing spondylitis patients
Phenotype Frequency (n (%)) Genotype concordance (%)
HLA-B27-positiveα rs4349859-positiveb rs116488202-positive rs4349859 rs116488202
Controls Caucasian 9/117 (7.7) 9/117 (7.7) 9/117 (7.7) 100.0 100.0
New Zealand Māori 7/107 (6.5) 6/107 (5.6) 6/107 (5.6) 85.7 85.7
AS Overall 164/176 (93.2) 159/176 (90.3) 159/176 (90.3) 96.9 97.6
Caucasian 151/162 (93.2) 149/162 (91.9)c 150/162 (92.6)d 98.7 99.3
New Zealand Māori 13/14 (92.9) 10/14 (71.4) 10/14 (71.4) 76.9 76.9

AS, ankylosing spondylitis; SNP, single nucleotide polymorphism.

αHLA-B27 status determined by human leucocyte antigen (HLA) typing.

bStudy participants were positive if heterozygous or homozygous for the minor allele of rs4349859 or rs116488202.

cOne patient was HLA-B*2705-positive by typing but was negative for the minor allele of both tagging SNPs.

dOne patient was HLA-B*2705-positive by typing but was negative for the minor allele of rs4349859.

Roberts et al.

Roberts et al. Arthritis Research & Therapy 2013 15:R158   doi:10.1186/ar4341

Open Data