Table 2

Cytokines assessed in supernatants of cultured CD1c+ myeloid dendritic cells derived from PB and SF of rheumatoid arthritis patients
PB (pg/ml) SF (pg/ml)
Proinflammatory cytokines
IL-1α 409 (150) 344 (343)
IL-1β 258 (65.5) 298 (280)
IL-1RA 2,561 (1,034) 2,769 (3,531)
IL-6 41.0 (13.3) 29.6 (22.6)
IL-6R 324 (100) 343 (199)
IL-18 149 (47.9) 180 (165)
Tumour necrosis factor alpha 99.1 (95.5) 170 (165)
Interferon alpha 153 (69.5) 157 (168)
Thymic stromal lymphopoeitin <LDL <LDL
T cell-differentiating and T cell-activating cytokines
IL-12p70 17.6 (11.1) 18.9 (18.5)
IL-23 444 (354) 420 (393)
IL-33 260 (101) 336 (391)
IL-13 857 (387) 1,054 (1,426)
IL-10 112 (49.9) 126 (63.1)
Macrophage migration inhibitory factor 1,872 (704) 2,948 (1,960)
IL-7 25.8 (6.9) 29.2 (29.7)
IL-9 3,087 (1,195) 3,280 (3,758)
IL-15 21.7 (8.7) 29.4 (27.3)
IL-21 5,114 (1,834) 6,343 (4,710)
IL-22 19.2 (6.1) 29.0 (27.3)
IL-25 1,140 (526) 1,239 (1,310)
Chemokines
IL-16 239 (101) 633 (581)
CCL2/MCP1 29.7 (18.5) 24.6 (25.5)
CCL3/MIP1α 1,268 (1,847) 2,776 (3,954)
CCL5/RANTES <LDL <LDL
CCL17/TARC 1.2 (0.5) 26.4 (23.6)**
CCL19/MIP3β 28.4 (11.5) 57.5 (51.5)
CCL22/MDC 4,397 (1,627) 2,456 (1,023)*
CXCL9/MIG 23.9 (16.1) 90.4 (67.9)**
CXCL10/IP-10 54.0 (70.3) 247 (310)*
Growth factors/others
Oncostatin M 28.0 (21.7) 23.5 (17.8)
Fibroblast growth factor basic 4,046 (1,647) 4,777 (5,559)
Nerve growth factor 63.0 (23.2) 76.7 (90.2)
Hepatocyte growth factor 118 (46.8) 151 (143)
Granulocyte–macrophage colony-stimulating factor 650 (283) 827 (859)
Macrophage colony-stimulating factor 484 (188) 571 (730)
Vascular endothelial growth factor 191 (110) 202 (125)
IL-11 49.6 (20.1) 53.6 (63.9)
Soluble intracellular adhesion molecule-1 34,067 (139,11) 37,260 (46,225)
Osteopontin 11,192 (4,471) 15,528 (10,471)
Matrix metalloproteinase-8 2,237 (1,594) 2,742 (4,634)
Tissue inhibitor of metalloproteinases-1 2,689 (1,126) 2,455 (2,169)
Cathepsin B 4,204 (1,554) 6,283 (4,948)
Cathepsin L 215 (101) 594 (731)
Cathepsin S 133 (55.3) 159 (130)

Data presented as mean (standard deviation). IP-10, interferon-gamma inducible protein-10; LDL, lower detection limit; MCP-1, monocyte chemotactic protein-1; MDC, macrophage-derived chemokine; MIG, monokine induced by interferon-gamma; MIP, macrophage inflammatory protein; PB, peripheral blood; RANTES, regulated upon activation, normally T cell-expressed, and presumably secreted; SF, synovial fluid; TARC, thymus and activation-regulated chemokine; IL, interleukin. *P <0.05; **P <0.01; P = 0.10.

Moret et al.

Moret et al. Arthritis Research & Therapy 2013 15:R155   doi:10.1186/ar4338

Open Data