mRNA expression levels of IL-17RA and IL-17RC in HD and SSc fibroblasts. Bars represent the mean ± SD of the mRNA levels at basal conditions of IL-17RA and IL-17RC normalized to the geometric mean of two house-keeping genes (GADPH, EEF1A1) in eight HD, eight lSSc and six dSSc fibroblasts. Significant differences were assessed by t-test.
dSSc: diffuse systemic sclerosis; EEF1A1: eukaryotic elongation factor 1 alpha 1; GADPH: glyceraldehyde 3 phosphate dehydrogenase; HD: healthy donors; IL: interleukin; lSSc: limited systemic sclerosis.
Brembilla et al. Arthritis Research & Therapy 2013 15:R151 doi:10.1186/ar4334