Table 4

Clinical parameters associated with antisynthetase syndrome deteriorationa
Characteristics ASS remission/improvement ASS deterioration P
(n= 68) (n= 18)
General characteristics
 Median age, years (range) 60.5 (17 to 86) 53 (19 to 83) 0.002
 Male/female ratio 39.7%/60.3% 27.8%/72.2% 0.420
 PM/DM subset 61.8% PM/38.2% DM 50% PM/50% DM 0.424
 Median duration of ASS symptoms before diagnosis, months (range) 3 (1 to 9) 4 (1 to 13) 0.680
Clinical characteristics
 Myalgia 82.4% 88.9% 1
 Muscle weakness 72% 94.4% 0.05
 Fever 16.2% 27.8% 0.309
 Raynaud’s phenomenon 48.5% 50% 1
 Mechanic’s hands 29.4% 33.3% 0.777
 Joint manifestations 66.2% 77.8% 0.406
 Esophageal involvement 19.1% 44.4% 0.03
 Interstitial lung disease 61.8% 72.2% 0.582
 Ventilatory insufficiency 10.3% 33.3% 0.02
 Pyogenic pneumonia 14.7% 38.9% 0.04
 Calcinosis cutis 2.9% 27.8% 0.004
 Malignancy 7.4% 38.9% 0.002

aASS: antisynthetase syndrome; PM/DM: polymyositis/dermatomyositis. P values were calculated using a χ2 test or Fisher’s exact test.

Marie et al.

Marie et al. Arthritis Research & Therapy 2013 15:R149   doi:10.1186/ar4332

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