Table 2

Esophageal complications and interstitial lung disease characteristics of anti-Jo1-positive antisynthetase syndrome patientsa
Complications and characteristics Percentage ( n )
Esophageal complications (N = 21)
 Time of onset
 Concomitant with PM/DM 19% (n = 4)
 1 to 3 months after PM/DM diagnosis 28.6% (n = 6)
 More than 3 months after PM/DM diagnosis 52.4% (n = 11)
 Presenting symptoms
  Odynophagia 4.8% (n = 1)
  Dysphagia 81% (n = 17)
  GER into pharynx and/or mouth 33.3% (n = 7)
  Coughing while eating 61.9% (n = 13)
  Aphagia for solids and liquids 14.3% (n = 3)
 Esophageal manometry
  Low pressure in upper esophageal sphincter 85.7% (n = 18)
  Decreased peristalsis in upper third of esophageal body 85.7% (n = 18)
  Absent peristalsis in upper third of esophageal body 14.3% (n = 3)
  Decreased peristalsis in lower two-thirds of esophageal body 9.5% (n = 2)
Interstitial lung disease (N = 55)
 Time of onset
  Before PM/DM 10.9% (n = 6)
  Concomitant with PM/DM 70.9% (n = 39)
  After PM/DM 18.2% (n = 10)
 PFT
  FVC (median) 74%
  VC (median) 75%
  DLCO (median) 61%
 HRCT scan pattern
  COP 12.7% (n = 7)
  NSIP 63.7% (n = 35)
  UIP 23.6% (n = 13)

aCOP: cryptogenic organizing pneumonia; DLCO: diffusing capacity of carbon monoxide; FVC: forced vital capacity; GER: gastroesophageal reflux; HRCT: high-resolution computed tomography; ILD: interstitial lung disease; NSIP: nonspecific interstitial pneumonia; PFT: pulmonary function test; PM/DM: polymyositis/dermatomyositis; UIP: usual interstitial pneumonia; VC vital capacity.

Marie et al.

Marie et al. Arthritis Research & Therapy 2013 15:R149   doi:10.1186/ar4332

Open Data