Additional file 4.

Replicate of analysis of cytokine levels in mice with reduced collagen-induced arthritis. For each sample and cytokine, measurements were repeated on a different day in order to have an independent replicate of the assay. At the end of the therapy 13 different cytokine concentrations were measured in plasma using multiplex bead-based flow cytometry. Data points of cytokine concentrations above detection level are represented in a scatter plot with the mean ± standard error of the mean (n=10). Standard curves defined with positive control samples (Additional file 6) were used to generate a level of quantification (LOQ; dotted red line).

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Doll et al. Arthritis Research & Therapy 2013 15:R138   doi:10.1186/ar4319