Frequency of IL-17+ and IL-22 + CD4+ in skin resident T cells of psoriatic skin lesions compared to healthy skin and interleukin 23 receptor coexpression in skin, synovial fluid and peripheral blood of psoriasis and psoriatic arthritis patients. Frequency of interleukin 17-positive (IL-17+) and IL-22+CD4+ in psoriatic skin lesions compared to healthy skin (A) and (B). Frequency of IL-17+IL-22+CD4+ T cells in psoriatic skin lesions compared to healthy skin (C). Representative fluorescence-activated cell sorting plots demonstrating CD4+ T-cell expression of IL-22 and IL-17 in psoriatic versus healthy skin (D). Percentages of Th22 cells in psoriatic and healthy skin (E). Percentage of CD4+ T cells coexpressing IL-23 receptor (IL-23R) in paired synovial fluid (Syn) and peripheral blood (PB) from psoriatic arthritis (PsA) patients and in skin and PB of psoriasis (Ps) patients (F). * p<0.05, **p<0.01, ***p<0.001.
Benham et al. Arthritis Research & Therapy 2013 15:R136 doi:10.1186/ar4317