Coexpression of cytokines and chemokines by CD4+ T cells in peripheral blood mononuclear cells of psoriatic arthritis patients, psoriasis patients and healthy controls. Coexpression of interleukin 22 (IL-22) and interferon γ (IFNγ) by IL-17+CD4+ T cells (A). Coexpression of IL-17 and IFNγ by IL-22+CD4+ T cells (B). Expression of IL-23 receptor (IL-23R) by CD4+ T cells (C) and the proportions of CD4+IL-17+ T cells (D) and CD4+IL-22+ T cells (E) coexpressing IL-23R. Expression of chemokine receptor 6 (CCR6) and CCR4 by IL-17+ T cells (F) and (G) and by IL-22+ T cells (H) and (I) in psoriasis (Ps) patients and psoriatic arthritis (PsA) patients compared with healthy controls. Coexpression of CCR6 and CCR4 by CD4+IL-17+ T cells (J) and CD4+IL-22+ T cells (K). * p<0.05, **p<0.01, ***p<0.001.
Benham et al. Arthritis Research & Therapy 2013 15:R136 doi:10.1186/ar4317