Table 2

Time course of composite measures and remission rate stratified by DAS28 (ESR) at discontinuation of ADA
DAS28 (ESR) ≤2.16 at discontinuation (n = 32) 2.16 <DAS28 (ESR) <2.6 at discontinuation (n = 18)
Week 0 Week 24 Week 0 Week 24
mean ± SD median (IQR) mean ± SD median (IQR) mean ± SD median (IQR) mean ± SD median (IQR)
TJC28 0.06 ± 0.25 0 (0, 0) 1.28 ± 3.27 0 (0, 1) 0.22 ± 0.55 0 (0, 0) 1.39 ± 2.09 0 (0, 2.5)
SJC28 0.03 ± 1.77 0 (0, 0) 0.41 ± 0.98 0 (0, 0) 0.0 ± 0.0 0 (0, 0) 1.17 ± 2.33 0 (0, 1)
PGA (mm) 5.41 ± 6.38 2 (0, 10) 9.75 ± 12.15 4.5 (0.3, 15.8) 8.72 ± 15.08 4 (1.5, 7.5) 16.17 ± 23.63 5 (0.75, 27)
EGA (mm) 2.25 ± 3.62 1 (0, 2.8) 7.22 ± 12.13 1.5 (0, 9.5) 2.50 ± 3.07 2 (0, 3.25) 10.72 ± 16.57 5.5 (0, 10.5)
ESR (mm/hr) 9.78 ± 4.11 9 (6.3, 12) 15.78 ± 10.07 14 (10, 18.8) 24.39 ± 9.05 24.5 (17.5, 32) 39.33 ± 20.55 37 (21.5, 53.75)
CRP (mg/dl) 0.11 ± 0.17 0.04 (0.01, 0.11) 0.35 ± 0.65 0.1 (0.05, 0.30) 0.11 ± 0.22 0.04 (0.03, 0.08) 0.22 ± 0.23 0.15 (0.04, 0.2)
CDAI 0.86 ± 1.00 0.4 (0.03, 1.5) 3.38 ± 5.95 1.0 (0.1, 3.0) 1.34 ± 1.83 0.6 (0.275, 1.7) 5.24 ± 7.32 2.2 (0.075, 9.2)
SDAI 0.97 ± 1.01 0.45 (0.2, 1.8) 3.74 ± 6.23 1.1 (0.3, 4.2) 1.44 ± 1.81 0.8 (0.3, 1.775) 5.45 ± 7.37 2.55 (0.275, 0.2)]
DAS28 (ESR) 1.65 ± 0.34 1.70 (1.45, 2.00) 2.30 ± 1.11 2.00 (1.80, 2.43) 2.41 ± 0.15 2.46 (2.27, 2.54) 3.24 ± 1.14 2.78 (2.54, 3.64)
HAQ 0.14 ± 0.23 0 (0, 0.3) 0.18 ± 0.39 0 (0, 0.1) 0.38 ± 0.38 0.31 (0, 0.66) 0.40 ± 0.44 0.25 (0, 0.78)
mTSS 27.86 ± 61.96 8 (2.5, 23) 64.41 ± 111.33 9 (0.5, 88)
n/N percent n/N percent n/N percent n/N percent
DAS28 (ESR) <2.6 32/32 100% 25/32 78.1% 18/18 100% 4/18 22.2%
DAS28 (ESR) <3.2 32/32 100% 27/32 84.4% 18/18 100% 11/18 61.1%
CDAI ≤2.8 31/32 96.9% 24/32 75.0% 15/18 83.3% 11/18 61.1%
SDAI ≤3.3 31/32 96.9% 23/32 71.9% 15/18 83.3% 11/18 61.1%
Boolean definition 25/32 78.1% 21/32 65.6% 15/18 83.3% 10/18 55.6%

CDAI, clinical disease activity index; CRP, C-reactive protein; DAS28 (ESR), disease activity score by using 28 joints based on erythrocyte sedimentation rate; EGA, evaluator’s global assessment; ESR, erythrocyte sedimentation rate; HAQ, Health Assessment Questionnaire; LOCF, last observation carried forward; mTSS, modified total Sharp score, Boolean definition: ACR/EULAR 2010 definition criteria of clinical remission (TJC ≤1, SJC ≤1, PGA ≤1 cm, CRP ≤1 mg/dl); PGA, patient’s global assessment; SDAI, simplified disease activity index; SJC, swollen joint count; TJC, tender joint count.

Hirata et al.

Hirata et al. Arthritis Research & Therapy 2013 15:R135   doi:10.1186/ar4315

Open Data