Table 5

Clinical Characteristics and the Risk of Progression of CAC (among those RA patients with Detectable CAC at baseline)
Demographics B (95% CI) Adjusted Ba (95% CI)
  Age, years -0.3 (-0.6, 1.3) NA
  Male sex 8.3 (-8.1, 24.6) NA
  Caucasian race; number (%) 28.0 (2.2, 53.7) NA
  Education; number (%) -2.8 (-22.1, 16.5) -2.3 (-24.3, 19.7)
   Some college or higher
Cardiovascular Risk Factors
  Diabetes; number (%) -6.5 (-32.5, 19.5) 9.8 (-18.8, 38.4)
  Hypertension (%) 13.1 (-2.3, 28.6) 5.4 (-14.6, 25.5)
   Systolic BP, mm Hg -0.3 (-0.8, 0.2) -0.2 (-0.8, 0.4)
   Diastolic BP, mm Hg 0.1 (-0.8, 1.0) 0.1 (-1.0, 1.2)
  Dyslipidemia (%) 16.7 (-1.2, 34.6) 14.0 (-4.8, 32.8)
   Total cholesterol, mg/dL -0.1 (-0.3, 0.1) -0.0 (-0.3, 0.2)
   LDL cholesterol, mg/dL 0.0 (-0.3, 0.2) 0.1 (-0.3, 0.4)
   HDL cholesterol, mg/dL -0.1 (-0.4, 0.4) 0.2 (-0.4, 0.9)
   Triglycerides, mg/dL -0.03 (-0.1, 0.0) -0.1 (-0.2, 0.0)
  Cigarette Smoking
   Current; number (%) 19. 9 (-5.7, 45.5) 10.8 (-19.5, 41.2)
Serum inflammatory markers at baseline
  CRP, mg/L; median (IQR) 3.2 (-3.5, 9.9) 4.4 (-3.0, 11.7)
  IL-6, pg/mL; median (IQR) -1.8 (-11.4, 7.8) -0.8 (-11.4, 9.9)
  Fibrinogen, mg/dL; median (IQR) 19.0 (-10.6, 48.5) 13.9 (-20.0, 47.8)
Disease characteristics at baseline
  Disease duration (years) 0.4 (-0.4, 1.2) 0.6 (-0.28, 1.5)
  RF 3.9 (-13.2, 21.0) 7.0 (-11.6, 25.6)
  Anti-CCP 4.2 (-15.9, 24.4) -1.5 (-25.5, 22.5)
  SE 2.2 (-16.2, 20.6) -6.8 (-27.8, 14.3)
  DAS28 5.1 (-2.4, 12.7) 6.5 (-1.5, 14.5)
  HAQ -5.1 (-17.6, 7.4) -0.8 (-16.5, 14.9)
  Sharp score -0.0 (- 0.1, 0.1) -0.0 (-0.1, 0.1)
  Current use of MTX -2.9 (-19.6, 13.7) -3.2 (-17.9, 23.2)
  Current use of biologic agents 15.8 (-1.5, 33.0) 18.5 (-1.4, 38.4)
  Current use of corticosteroids -8.6 (-25.8, 8.1) -5.3 (-26.1, 15.3)
  Disease characteristics, expressed as average over follow-up
  DAS28 2.0 (-7.6, 11.6) 4.8 (-6.0, 15.5)
  CRP -3.9 (-11.2, 3.5) -1.1 (-9.7, 7.5)
  IL-6 -5.4 (-13.6, 2.9) -6.0 (-16, 4.0)
  Fibrinogen pg/mL; median (IQR) -7.3 (-45, 29) -6.1 (-50, 38)

aAdjusted for age, sex, race, hypertension, diabetes, smoking, dyslipidemia. BP, blood pressure; CAC, coronary artery calcium; CCP, cyclic citrullinated peptide; CRP, C-reactive protein; DAS28, disease activity score in 28 joints; HAQ, Health Assessment Questionnaire; HDL, high density lipoprotein; IQR, interquartile range; IRR, incidence rate ratio; LDL, low density lipoprotein; MTX, methotrexate; RA, rheumatoid arthritis; rheumatoid factor; RR, relative risk; SE, shared epitope.

Chung et al.

Chung et al. Arthritis Research & Therapy 2013 15:R134   doi:10.1186/ar4314

Open Data