Table 3

Top 10 molecules which demonstrated the highest upregulation and downregulation in treated discs.

Gene symbol

Gene description

Expression levels


ORM1/ORM2

Orosomucoid 1

31.714

CCL20

Chemokine (C-C motif) ligand 20

24.260

TFPI2

Tissue factor pathway inhibitor 2

23.074

IL6

Interleukin 6

21.493

MMP3

Matrix metallopeptidase 3

21.267

CYP7B1

Cytochrome P450, family 7, subfamily b,

20.756

ADAMTS5

ADAM metallopeptidase with thrombospondin type 1 motif, 5

19.843

LCN2

Lipocalin 2

18.146

PTGES

Prostaglandin E

15.958

INHBA

Inhibin beta-A

15.593

KRT19

Keratin 19

-26.767

ASPN

Asporin

-17.890

KRT8

Keratin 8

-14.161

IBSP

Integrin-binding sialoprotein

-12.914

COL1A2

Collagen, type I, alpha 2

-10.794

Lyz1/Lyz2

Lysozyme

-8.718

H19

Imprinted maternally expressed transcript

-8.222

COL1A1

Collagen, type I, alpha 1

-7.395

IGF1

Insulin-like growth factor 1

-6.578

CRYAB

Crystallin, alpha B

-6.199


Markova et al. Arthritis Research & Therapy 2013 15:R121   doi:10.1186/ar4301

Open Data