Effects of IL-1β and TNF-α on stimulated migration of CPC. Chondrogenic progenitor cells CPC migration was stimulated with platelet-derived growth factor (PDGF) (10 ng/ml), IGF (100 ng/ml) or supernatant of impacted cartilage (supernatant (SN) trauma) and inhibited with interleukin (IL)-1β (1 ng/ml) and tumor necrosis factor (TNF)-α (10 ng/ml), control cells remained unstimulated. The values represent the mean ± SEM with n ≥3. Statistical significance was evaluated by ANOVA followed by a Bonferroni multiple comparison post-test with *P < 0.05, **P < 0.01 and ***P < 0.001.
Joos et al. Arthritis Research & Therapy 2013 15:R119 doi:10.1186/ar4299