Table 3

Univariate analysis of baseline clinical and MSUS parameters

Clinical/Laboratory Parameters:

Overall cohort (n = 379)

Outcome diagnostic category


Non-PIA (n = 217);

PIA (n = 162);

P-value†


Age (years)

-cat; >50 (%)

51

49

51

0.533

-cont; mean (SD)

50.9 (36 to 66.)

48.5 (34.5 to 62.5)

53.8 (37.8 to 69.8)

0.057


Sex; F (%)

69

71

67

0.540


Ever smoked? (%)

54.1

100, 117

74, 88

0.999


Sx durn (weeks)

-cat; ≥20 (%)

51

61

38

<0.001

-cont; median (IQR)

20 (10 to 34)

24 (12 to 52)

12 (8 to 24)

<0.001


TJC /72

-cat; >6 (%)

51

48

54

0.299

-cont; median (IQR)

7 (2 to 14)

6 (2 to 14)

7.5 (3 to 15)

0.052


SJC /72

-cat; ≥1 (%)

46

26

73

<0.001

-cont; median (IQR)

0 (0 to 3)

0 (0 to 1)

2 (0 to 6)

<0.001


JPS

-cat; ≥2 (%)

66

56

78

<0.001

-cont; median (IQR)

2 (1.5 to 2)

2 (1.5 to 2)

2 (2 to 2.5)

<0.001


EMS (hours)

-cat; ≥1 (%)

50

39

65

<0.001

-cont; median (IQR)

1 (0.2 to 2)

0.5 (0.05 to 1.5)

1 (0.5 to 2)

<0.001


CRP (g/l)

-cat; <5,5 to 14,≥14 (%)

49,26,25

66, 23, 11

25, 30, 45

<0.001

-cont; median (IQR)

5 (<5 to 14)

<5 (<5 to 8)

11 (<5 to 32)

<0.001


ESR (mm/hr)

-cat; >24 (%)

50

33

72

<0.001

-cont; median (IQR)

24 (13 to 50)

18 (9 to 13)

45 (24 to 67)

<0.001


RF; Pos (%)

Neg, Pos

193, 24

97, 65

<0.001


ACPA; Pos (%)

Neg, Pos

216, 1

107, 55

<0.001


MSUS Parameters

Domain/Parameter

Definition


Grey-sale synovotis

∑ semi-quant. score/16 joints:

≥2 (%)

35.1

19.4

56.2

<0.001


∑ semi-quant score/6 joints (worst hand): ≥2 (%)

29.6

15

48.8

<0.001


Number of joints/16 scoring ≥1:

≥3 (%)

30.1

14.7

50.6

<0.001


Power Doppler synovitis

∑ semi-quant. Score/16 joints:

≥1 (%)

29

15.7

46.9

<0.001


Number of joints/16 scoring ≥1:

≥2 (%)

16.9

7.4

29.6

<0.001


Baseline data for study cohort, and univariate analysis amongst patients with persistent inflammatory versus non-inflammatory diagnostic outcomes. Clinical and laboratory parameters are considered in both continuous (cont.) and categorical (cat.) formats. ACPA, anti-citrullinated peptide antibody; EMS, early morning stiffness; IQR, inter-quartile range; JPS, joint pattern score; RF, rheumatoid factor; SD, standard deviation, SxDur, symptom duration; T/SJC, tender/swollen joint count, (see Methods for derivation). Baseline MSUS data and corresponding univariate analysis (employing predetermined, optimal cut-off values for each dichotomous parameter) is also presented. ∑, sum of, semi-quant, semi-quantitative; PIA, persistent inflammatory arthritis. *Mann-Whitney U/Student's t tests for skewed/normally-distributed continuous data respectively; Pearson's χ2 with Yates' continuity correction for dichotomous data.

Pratt et al. Arthritis Research & Therapy 2013 15:R118   doi:10.1186/ar4298

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