The effect of nitric oxide (NO) on chondrocyte viability depends on glucose levels. Articular chondrocytes were cultured in medium with crescent glucose concentrations and treated with 1 mM sodium nitroprusside (SNP) and 1 mM N-ethyl-2(1-ethyl-2 hydroxy-2-nitrosohydrazine (NOC-12) for 24 hours. Data are expressed as a percentage of apoptotic (hypodiploid) nuclei. Values are the mean ± SD; n = 3.
de Andrés et al. Arthritis Research & Therapy 2013 15:R115 doi:10.1186/ar4295