Open Access Research article

Evaluation of bone marrow lesion volume as a knee osteoarthritis biomarker - longitudinal relationships with pain and structural changes: data from the Osteoarthritis Initiative

Jeffrey B Driban1*, Lori Lyn Price2, Grace H Lo34, Jincheng Pang5, David J Hunter6, Eric Miller5, Robert J Ward7, Charles B Eaton8, John A Lynch9 and Timothy E McAlindon1

Author Affiliations

1 Division of Rheumatology, Tufts Medical Center, 800 Washington Street, Box No 406, Boston, MA 02111, USA

2 The Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, and Tufts Clinical and Translational Science Institute, Tufts University, 800 Washington Street, Box No 63, Boston, MA 02111, USA

3 Medical Care Line and Research Care Line; Houston Health Services Research and Development (HSR&D) Center of Excellence Michael E. DeBakey VAMC, 2002 Holcombe Boulevard, Houston, TX 77030, USA

4 Section of Immunology, Allergy, and Rheumatology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA

5 Department of Electrical and Computer Engineering, Tufts University, 101A Halligan Hall, Medford, MA 02155, USA

6 Royal North Shore Hospital, Rheumatology Department and University of Sydney, Reserve Road, St Leonards, NSW 2065, Australia

7 Department of Radiology, Tufts Medical Center, 800 Washington Street, Box No 299, Boston, MA 02111, USA

8 Center for Primary Care and Prevention, Alpert Medical School of Brown University, 111 Brewster St, Pawtucket, RI 02860, USA

9 Department of Epidemiology and Biostatistics, University of California at San Francisco, 185 Berry Street, San Francisco, CA 94107, USA

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Arthritis Research & Therapy 2013, 15:R112  doi:10.1186/ar4292

Published: 10 September 2013

Additional files

Additional file 1:

Figure S1. Classification and regression trees intended to classify participants with and without joint space narrowing progression. The analysis classified participants with baseline bone marrow lesion (BML) volume less than 0.95 cm3 as participants without joint space narrowing (JSN) progression. For participants with baseline BML volume greater than 0.95 cm3, classification into the progressor and non-progressor groups depended on further splits based on change in BML volume, baseline BML volume, and age.

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