Table 1

Studies assessing the relationship between functional and morphological measures of endothelial function.

Authors

Participants

Vascular assessment

Associations


Healthy


Juonala et al. 2004 [52]

2109 healthy (age: 32 ± 5 years)

FMD, cIMT

FMD inversely associated with cIMT


Yeboah et al. 2008 [29]

2338 healthy (age 78 ± 4)

FMD, cIMT

No significant associations


Koivistoinen et al. 2012 [30]

1754 healthy (young) (age: 30 - 45) & 336 healthy (older) (age: 46 - 76)

FMD, PWV, cIMT

No significant associations


Lunder et al. 2012 [50]

100 healthy males (age: 42 ± 6)

FMD, GTN, PWV, cIMT

FMD inversely associated with PWV


Irace et al. 2006 [31]

77 healthy

FMD, GTN, cIMT

No significant associations


Yan et al. 2005 [32]

1,578 healthy males (age: 49 ± 10)

FMD, GTN, cIMT

No significant associations


Coronary artery disease


Rohani et al. 2005 [39]

58 CAD (age: 67 ± 9)

FMD, cIMT, carotid plaque

No significant associations


Simova et al. 2008 [33]

198 CAD (age: 60 ± 10

FMD, cIMT

FMD inversely associated with cIMT


Furumoto et al. 2002 [34]

45 CAD (age: 61 ± 11)

FMD, GTN, cIMT

FMD inversely associated with cIMT


Hashimoto et al. 1999 [53]

34 CAD males (age: 61 ± 2) & 33 age-matched healthy controls

FMD, GTN, cIMT

FMD inversely associated with cIMT when both populations combined, and when analysis was performed in healthy controls only

&

GTN inversely associated with cIMT when both populations combined


Enderle et al. 1998

[54]

101 CAD (age: 60 ± 8.6) & 21 non-CAD (age: 57 ± 8.2)

FMD, GTN, cIMT

FMD inversely associated with cIMT


Diabetes


Ravikumar et al. 2002

[55]

50 diabetics (age: 54 ± 10) & 50 healthy age- & sex-matched controls

FMD, AIx, cIMT

FMD inversely associated with AIx and cIMT when both populations combined, and when analysis was performed in healthy controls only

&

FMD inversely associated with AIx in diabetics


Rheumatoid arthritis


Arosio et al. 2007 [23]

65 RA females (age: 41 - 52)

FMD, PWV

FMD inversely associated with PWV in RA


Kerekes et al. 2008 [25]

52 RA (age: 51 ± 12)

FMD, GTN, cIMT

FMD inversely associated with cIMT


Soltesz et al. 2009

[24]

101 patients with autoimmune disease (age: 52 ± 13)

FMD, AIx, PWV, cIMT

FMD inversely associated with AIx, PWV and cIMT


Van Doornum et al. 2003

[60]

25 RA (age: 46 ± 8)

FMD, GTN, PWA

FMD not associated with PWA


AIx, augmentation index; cIMT, carotid intima-media thickness; CAD, coronary artery disease; FMD, flow-mediated dilatation; GTN, glyceryl-trinitrate mediated dilatation; PWV, pulse wave velocity; RA, rheumatoid arthritis.

Sandoo et al. Arthritis Research & Therapy 2013 15:R107   doi:10.1186/ar4287

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