Additional file 1.

A supplementary file containing. 1) Supplementary methods containing details of the OAI database, ethical approval and eligibility assessment, and OAI exclusion criteria. 2) Supplementary results containing details of the robustness of patient reported medication use and the combinations of medications used by participants. 3) Supplementary Table S1 showing combinations of analgesics and nutraceuticals taken by subjects at baseline. 4) Supplementary Table S2 showing changes in nutraceutical use at 36 months relative to baseline according to demographic and clinical variables and change in pain. 5) Supplementary Table S3 showing changes in analgesic medication use over 36 months according to demographic and clinical variables and change in pain.

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Kingsbury et al. Arthritis Research & Therapy 2013 15:R106   doi:10.1186/ar4286