Table 3

Laboratory parameters before and after rosuvastatin treatment in SSc patients

Parameter

Pre-treatment mean (S.D.)

Post-treatment mean (S.D.)

P valuea


Erythrocyte sedimentation rate (mm/hour)

21 (15.6)

24.7 (19)

ns (0.15)

CRP (mg/L)

5.1 (5.2)

3.4 (2.7)

0.01

Glucose (mmol/L)

5.3 (1.0)

5.5 (1.3)

ns (0.24)

Urea (mmol/L)

6.0 (2.4)

5.9 (2.5)

ns (0.5)

Creatinine (μmol/L)

67.5 (19.7)

63 (16.9)

ns (0.062)

GFR (ml/min)

82.1 (14.0)

84.8 (10.8)

ns (0.078)

Triglyceride (mmol/L)

1.7 (0.97)

1.3 (0.46)

0.0004

Total cholesterol (mmol/L)

5.3 (1.57)

4.2 (1.28)

0.0003

LDL (mmol/L)

3.0 (1.3)

2.2 (1.0)

0.005

Non-HDL (mmol/L)

3.8 (1.5)

2.5 (1.3)

0.0003

HDL (mmol/L)

1.5 (0.84)

1.5 (0.6)

ns (0.33)

Uric acid (μmol/L)

263 (56)

273 (77)

ns (0.22)

von Willebrand factor (%)

209 (90)

193 (75.6)

ns (0.092)

Hemoglobin (g/L

125 (12.7)

126 (12.5)

ns (0.242)

White blood cell count (109/L)

6.7 (2.6)

7.1 (2.7)

ns (0.191)

Platelet count (109/L)

250 (62)

265 (64.5)

ns (0.064)

Complement 3 (g/L)

1.81 (0.4)

1.62 (0.32)

0.001

Complement 4 (g/L)

0.31 (0.13)

0.27 (0.1)

0.001

Immune complex (extinction)

183.6 (110)

135.5 (55)

0.005


aSignificant differences are indicated in bold, CRP, C-reactive protein; GFR, glomerular filtration rate; HDL, high-density cholesterol; LDL, low-density cholesterol; ns, non-significant; SSc, systemic sclerosis.

Timár et al. Arthritis Research & Therapy 2013 15:R105   doi:10.1186/ar4285

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