Table 3

HMGB1 levels as a biomarker of relapse risk in antineutrophil cytoplasmic antibodies-associated vasculitis patients

HMGB1 levels

Hazard rate

95% confidence interval

P value


At baseline

0.812

0.529 to 1.248

0.327

At early remissiona

0.963

0.641 to 1.446

0.854

At ongoing remission

1.344

0.746 to 2.420

0.325

Prior to relapse 1

0.967

0.776 to 1.205

0.762

Delta between early remission and prior to relapse 1

0.959

0.751 to 1.226

0.739

Delta between ongoing remission and prior to relapse 1

0.919

0.728 to 1.161

0.478


Cox hazard proportional model to evaluate the role of HMGB1 levels as a biomarker of relapse risk in antineutrophil cytoplasmic antibodies-associated vasculitis patients. HMGB1, high-mobility group box 1. aEarly remission indicates when remission was achieved.

de Souza et al. Arthritis Research & Therapy 2013 15:R104   doi:10.1186/ar4284

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