Longitudinal fluctuation of HMGB1 levels in different phases of the disease in AAV patients. High-mobility group box 1 (HMGB1) levels decrease significantly from presentation to when remission was induced (P = 0.006) but returned to levels similar to baseline at ongoing remission. No significant changes in HMGB1 levels were observed prior to or during disease relapses in antineutrophil cytoplasmic antibodies-associated vasculitis (AAV) patients. Box and whisker plots indicate the 25 to 75% range (boxes), the 5 to 95% range (error bars), and the median value (horizontal lines); dots represent outliers.
de Souza et al. Arthritis Research & Therapy 2013 15:R104 doi:10.1186/ar4284