Table 3

Genes differentially expressed by cartilage calcification in samples from six patients with osteoarthritis

Gene name

Gene ID

Differential gene expression (fold-change) compared with OA cartilage without calcification


CPP crystals

CA crystals

CPP + CA


OA1

OA2

OA3

Mean

OA4

OA5

Mean

OA6


ENPP1 (PC-1)

MIM 173335

2.98

2.29

2.59

2.62**

2.54

1.09

1.81 (NS)

2.5

ANKH

MIM 605145

3.54

2.67

4.94

3.72*

2.66

1.83

2.24 (NS)

1.82

TNAP

MIM 171760

2.20

7.74

56.10

22.01 (NS)

9.26

2.20

5.73 (NS)

2.17

SLC20A1 (Pit1)

MIM 137570

1.55

1.34

0.82

1.24 (NS)

1.82

1.63

1.72 (NS)

1.19

NT5E (CD73)

MIM 129190

0.82

1.27

0.78

0.96 (NS)

2.00

0.57

1.28 (NS)

1.59


ANKH, ankylosis progressive homolog; CA, carbonated apatite; CPP, calcium pyrophosphate; ENPP1, ectonucleotide pyrophosphatase 1; NS, not significant; NT5E, 5'-nucleotidase (ecto) or CD73 protein; OA, osteoarthritis; SLC20A1, solute carrier family 20 (phosphate transporter), member 1 or Pit1; TNAP, tissue nonspecific alkaline phosphatase. **P < 0.01 (vs. samples without calcification), *P < 0.05 (vs. samples without calcification).

Nguyen et al. Arthritis Research & Therapy 2013 15:R103   doi:10.1186/ar4283

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