Table 5

IPA canonical pathways were significantly affected in ageing cartilage

Name of canonical pathway

P value

Ratio


Atherosclerosis signalling

3.80 × 10-9

15/136 (0.11)

Role of osteoblasts, osteoclasts and chondrocytes in rheumatoid arthritis

3.41 × 10-6

16/238 (0.067)

Intrinsic prothrombin activation

9.82 × 10-6

6/35 (0.171)

Hepatic fibrosis and stellate cell activation

9.92 × 10-6

12/146 (0.082)

Role of macrophages, fibroblasts and endothelial cells in rheumatoid arthritis

1.73 × 10-4

16/333 (0.048)


The significance of the association between the dataset and the canonical pathway was measured using a ratio of the number of molecules from the dataset that mapped to the pathway divided by the total number of molecules that map to the canonical pathway is displayed. Fisher's exact test was used to calculate P values.

Peffers et al. Arthritis Research & Therapy 2013 15:R98   doi:10.1186/ar4278

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