Table 3

SNORDs and SNORAs identified as being differentially expressed in ageing cartilage.

Name

Family

Action

Target

Log2 fold-change

Higher


SNORD113

C/D BOX

Site-specific 2'-O-methylation

Not predicted to target rRNA or snRNA.

29.6

Young

SNORA53

H/ACA box

H/ACA family of pseudouridylation guide snoRNAs

Not identified

29.9

Young

SNORA79

H/ACA box

H/ACA family of pseudouridylation guide snoRNAs

Not identified

5.3

Young

SNORA48

H/ACA box

H/ACA family of pseudouridylation guide snoRNAs

28SrRNA

4.1

Young

SNORD12/SNORD16

C/D BOX

Site-specific 2'-O-methylation

28srRNA, 18SrRNA

3.2

Young

RNase P

RNase MRP related

Site-specific endonuclease, ribosome biogenesis, pre-rRNA processings

Numerous

1.7

Young

Rnase MRP

Rnase MRP

Site-specific endonuclease

Numerous

2

Young

U1 splicesomal RNA

Splicesome

Complex of snRNA and protein subunits that removes introns from a transcribed pre-mRNA

2.3

Young

U2 splicesomal RNA

Splicesome

Complex of snRNA and protein subunits that removes introns from a transcribed pre-mRNA

2.3

Young

SNORA40

H/ACA box class

H/ACA family of pseudouridylation guide snoRNAs

28SrRNA

-1.5

Old

SNORA5

H/ACA box class

H/ACA family of pseudouridylation guide snoRNAs

Not identified

-1.9

Old

SNORA30/SNORA37

H/ACA box class

H/ACA family of pseudouridylation guide snoRNAs

28SrRNA

-2.7

Old

Small nucleolar RNA U89

H/ACA box class

H/ACA family of pseudouridylation guide snoRNAs

Not identified

-1.4

Old

U4 splicesomal RNA

Splicesome

Complex of snRNA and protein subunits that removes introns from a transcribed pre-mRNA

-2.2

Old

U6 splicesomal RNA

Splicesome

Complex of snRNA and protein subunits that removes introns from a transcribed pre-mRNA

-2.1

Old


The class of action and target of these RNAs are shown with higher differential gene expression (DGE) in young or old cartilage. rRNA, ribosomal RNA; snoRNA, small nucleolar RNA.

Peffers et al. Arthritis Research & Therapy 2013 15:R98   doi:10.1186/ar4278

Open Data