Top-scoring networks derived from the 352 genes differentially expressed in ageing. (A) Ingenuity pathway analysis (IPA) identified connective tissue disorders as the principle associated network functions with scores of 43. (B) The second top-scoring network was a further connective tissue disorder with scores of 35. (C) IPA identified ageing significantly affected the connective tissue development and function network in ageing cartilage. Figures are graphical representations between molecules identified in our data in their respective networks. Green nodes, upregulated gene expression in older cartilage; red nodes, downregulated gene expression in older cartilage. Intensity of colour is related to higher fold-change. Key to the main features in the networks is shown.
Peffers et al. Arthritis Research & Therapy 2013 15:R98 doi:10.1186/ar4278