Table 6

Relationships of disease activity and severity with systemic inflammation in moderately or highly active RA

C-reactive proteina

Interleukin-6a



Disease activity variable

Age and sex adjusted model

Multivariable adjusted modelb

Age and sex adjusted model

Multivariable

adjusted modelb


Partial R

P

Partial R

P

Partial R

P

Partial R

P

Swollen jointsa

0.025

0.9

0.113

0.4

-0.260

0.07

-0.246

0.1

Tender jointsa

0.028

0.8

0.014

0.9

-0.131

0.4

-0.120

0.4

Doctor disease activitya

0.100

0.5

0.084

0.6

0.212

0.2

0.232

0.1

Patient disease activity

-0.092

0.5

-0.066

0.7

0.222

0.1

0.225

0.2

CDAIa

0.066

0.6

0.111

0.5

0.125

0.4

0.147

0.3

Deformed jointsa

0.041

0.8

0.028

0.8

0.012

0.9

-0.050

0.7


Sixty-one patients had moderate or high disease activity (CDAI > 10). aNon-normally distributed variables that were logarithmically transformed; badditionally adjusted for potential confounders of body mass index, waist:height ratio and angiotensin converting enzyme inhibitors (see Table 3). CDAI, Clinical Disease Activity Index.

Dessein et al. Arthritis Research & Therapy 2013 15:R96   doi:10.1186/ar4276

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