Table 2

Conventional cardiovascular risk factors, systemic inflammation and atherosclerosis in African black subjects by RA status

Rheumatoid arthritis

Adjusted models



Characteristic

Present (n = 115)

Absent (n = 159)

Model 1a

Model 2b

Model 3c

Model 4d

Model 5e


Categorical variables

OR (95% CI)

OR (95% CI)

OR (95% CI)

OR (95% CI)

OR (95% CI)

Hypertension (%)

74.8

65.4

1.65 (0.95 to 2.96)

1.66 (0.94 to 2.96)

2.03 (1.07 to 3.85)

-

1.88 (0.97 to 3.67)

T chol/HDL chol >4

21.6

33.5

0.54 (0.30 to 1.00)

0.73 (0.40 to 1.33)

0.64 (0.31 to 1.30)

0.87 (0.31 to 3.07)

0.88 (0.28 to 2.79)

Smoking

Ever (%)

16.5

14.5

1.37 (0.66 to 2.85)

-

-

-

-

Former (%)

13.0

6.9

2.48 (1.03 to 5.99)

-

-

-

-

Current (%)

3.5

7.6

0.46 (0.14 to 1.51)

-

-

-

-

Diabetes (%)

15.7

12.0

1.41 (0.69 to 2.85)

1.87 (0.86 to 4.06)

-

1.48 (0.37 to 5.99)

1.53 (0.38 to 6.28)

≥1 major RF (%)

75.7

78.1

0.87 (0.49 to 1.53)

0.86 (0.48 to 1.53)

0.66 (0.24 to 1.81)

1.23 (0.34 to 4.12)

0.88 (0.28 to 3.79)

Continuous variables

Partial R P

Partial R P

Partial R P

Partial R P

Partial R P

Blood pressure values

Systolic BP, mmHg

140 (25)

137 (22)

0.064 0.3

0.035 0.6

0.080 0.2

-

0.092 0.2

Diastolic BP, mmHg

86 (15)

87 (13)

-0.038 0.5

-0.031 0.6

-0.008 0.9

-

-0.017 0.8

Lipid values

T chol, mmol/l

4.7 (0.9)

5.1 (1.2)

-0.145 0.02

-0.112 0.08

-0.126 0.045

-0.075 0.2

-0.072 0.3

HDL cholf, mmol/l

1.48 (1.33)

1.39 (1.32)

0.112 0.07

0.082 0.2

0.094 0.1

-0.001 1.0

0.026 0.7

T chol/HDL chol

3.2 (1.0)

3.7 (1.3)

-0.180 0.003

-0.134 0.03

-0.155 0.01

-0.041 0.5

-0.064 0.4

LDL chol, mmol/l

2.6 (0.8)

3.0 (1.0)

-0.173 0.005

-0.133 0.04

-0.146 0.02

-0.096 0.1

-0.120 0.09

LDL chol/HDL cholf

1.68 (1.55)

2.02 (1.59)

-0.179 0.004

-0.134 0.03

-0.147 0.02

-0.070 0.3

-0.110 0.1

Non HDL, mmol/l

3.1 (0.9)

3.6 (1.2)

-0.190 0.002

-0.145 0.02

-0.165 0.009

-0.081 0.2

-0.090 0.2

Trigf, mmol/l

1.08 (1.70)

1.20 (1.59)

-0.118 0.06

-0.093 0.14

-0.119 0.06

-0.058 0.4

-0.041 0.6

Trig/HDL cholf

0.73 (2.02)

0.87 (1.83)

-0.139 0.02

-0.110 0.08

-0.135 0.03

-0.046 0.5

-0.046 0.6

Smokingf, cigarettes/d

0.05 (0.36)

0.15 (0.68)

-0.096 0.1

-

-

-

-

Glucose f, mmol/l

5.2 (1.4)

5.5 (1.4)

-0.117 0.06

-0.090 0.2

-

-0.095 0.1

-0.088 0.2

Major RF, number

1.1 (0.8)

1.2 (0.9)

-0.024 0.7

0.010 0.9

0.008 0.9

0.035 0.6

0.023 0.7

10 year risk for CHD f

2.5 (3.0)

3.2 (3.2)

-0.103 0.1

-0.090 0.2

-0.057 0.4

-0.042 0.5

-0.012 0.9

10 year risk for CVD f

9.3 (2.2)

10.4 (2.4)

-0.050 0.4

-0.012 0.9

0.035 0.6

0.001 1.0

-0.002 1.0

Systemic inflammation

CRP, mg/l f

7.2 (3.1)

6.7 (3.1)

0.024 0.7

0.099 0.1

-

-

-

Interleukin-6, pg/ml f

3.9 (1.9)

6.3 (1.9)

-0.344 <0.0001

-0.296 <0.0001

-

-

-

Atherosclerosis

cIMT, mm

0.700 (0.085)

0.701 (0.111)

0.025 0.7

0.062 0.4

0.076 0.3

0.013 0.9

0.036 0.7


Results are expressed as mean (SD) or proportions/percentages. Significant associations are shown in bold. aAdjusted for age and sex; badditionally adjusted for body mass index and waist to height ratio; cadditionally adjusted for leflunomide use; dadditionally adjusted for chloroquine use; eadditionally adjusted for serum C-reactive protein and interleukin-6 concentrations; the number of antihypertensive agents employed and use of statins and oral glucose lowering agents as well as insulin were additionally adjusted for in models that included blood pressure and lipid variables and glucose concentrations, respectively; fnon-normally distributed variables for which geometric mean (SD) is given. RA, rheumatoid arthritis; BP, blood pressure; CHD, coronary heart disease; cIMT, common carotid intima-media thickness; CRP, C-reactive protein; CVD, cardiovascular disease; HDL chol, high density lipoprotein cholesterol; trig, triglycerides; LDL chol, low density lipoprotein cholesterol; RF, risk factors; T chol, total cholesterol

Dessein et al. Arthritis Research & Therapy 2013 15:R96   doi:10.1186/ar4276

Open Data