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Open Access Research article

Small molecule inhibitors of WNT/β-catenin signaling block IL-1β- and TNFα-induced cartilage degradation

Ellie BM Landman1, Razvan L Miclea2, Clemens A van Blitterswijk3 and Marcel Karperien1*

Author Affiliations

1 Department of Developmental BioEngineering, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Drienerlolaan 5, 7522 NB Enschede, the Netherlands

2 Department of Pediatrics, Leiden University Medical Centre, Einthovenweg 20, 2333 ZC Leiden, the Netherlands

3 Department of Tissue Regeneration, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Drienerlolaan 5, 7522 NB Enschede, the Netherlands

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Arthritis Research & Therapy 2013, 15:R93  doi:10.1186/ar4273

Published: 21 August 2013

Additional files

Additional file 1:

Figure S1 Small molecule inhibitors do not affect mouse fetal metatarsals. (A) No morphological changes were found in metatarsals treated with small molecules PKF115-584, PKF118-310 or CGP049090 at a concentration of 1.0 µM. A representative picture of two independent experiments is shown. Scale bar represents 500 µm. (B) No significant differences were found in the bone length when metatarsals were treated with small molecules. Data are means with 95% confidence intervals of three independent experiments.

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