Table 2

Test performance characteristics of SE, anti-CCP and RF for RA association

Parameter

Patients

% (n)

Controls

% (n)

PPV

NPV

Specificity

sensitivity

OR

95% CI

P-value


SE

positive

35.1 (13)

12.5 (3)

81

47

87

35

3.8

0.9 to 15.1

0.07

negative

64.9 (24)

87.5 (21)

RF

positive

34.7 (25)

3.0 (2)

93

58

97

35

17.3

3.9 to 76.6

<0.0001

negative

65.2 (47)

97.0 (65)

anti-CCP

positive

47.2 (34)

3.0 (2)

94

63

97

47

29.1

6.6 to 127.9

<0.0001

negative

52.7 (38)

97.0 (65)


Anti-CCP, anti-cyclic citrullinated peptide; NPV, negative predictive value; PPV, positive predictive value; RA, rheumatoid arthritis; RF, rheumatoid factor; SE, shared epitope

Malemba et al. Arthritis Research & Therapy 2013 15:R89   doi:10.1186/ar4269

Open Data