Study flow. Responders were defined as patients who received a minimum dosage of milnacipran 100 mg/day and achieved ≥50% pain improvement after long-term treatment. aPatients not meeting responder criteria were analyzed separately, but the results for these patients are not presented in the current report. "Nonresponder" does not necessarily imply no improvement. bWorsening of fibromyalgia requiring alternative treatment, which was one of the loss of therapeutic response (LTR) criteria used for the primary efficacy analysis and for sensitivity analysis III. cPatients reaching the final study visit. dOne patient who did not receive at least one dose of the study drug was excluded from safety and efficacy analyses. OL = open-label.
Clauw et al. Arthritis Research & Therapy 2013 15:R88 doi:10.1186/ar4268