Table 4

Variables associated with measures of atherosclerosis in systemic sclerosis patients after age adjustment.

Plaques (n = 52)

IMT

ABI


Odds ratio

(95% CI)

P value

β-coefficient

P value

β-coefficient

P value


Age

1.09 (1.05-1.14)

<0.0001

0.66

<0.0001

-0.20

0.03


Associations after adjustment for age


Gender female

0.39 (0.12-1.18)

0.1

-0.19

0.0001

-0.12

0.2

ACA+

2.9 (1.2-7.5)

0.02

-0.01

0.9

-0.14

0.2

Digital ulcers

2.6 (1.1-6.6)

0.03

0.10

0.2

-0.09

0.4

Kidney disease

11.5 (1.7-232)

0.03

-0.05

0.5

0.05

0.6

Disease activity

1.6 (1.04-2.5)

0.03

0.10

0.2

-0.34

0.0004

Disease severity

1.3 (1.1-1.5)

0.005

0.12

0.1

0.13

0.2

Waist-hip ratio

2.6 (0.01-645)

0.7

0.09

0.2

0.19

0.04

Ever smoked

2.5 (1.05-6.7)

0.04

0.10

0.2

0.24

0.01

Systolic BP

1.0 (1.0-1.1)

0.02

0.28

0.0008

-0.06

0.6

Diastolic BP

1.1 (1.0-1.1)

0.008

0.13

0.1

-0.02

0.9

Interleukin-6

3.5 (1.5-9.3)

0.003

0.12

0.1

-0.13

0.2

VCAM-1

9.4 (1.8-58.3)

0.008

-0.05

0.5

0.03

0.8

ICAM-1

0.32 (0.05-1.98)

0.2

0.16

0.04

-0.12

0.2

eGFR

0.4 (0.2-0.99)

0.04

0.11

0.2

-0.04

0.7


IMT, intima-media thickness; ABI, ankle-brachial index; CI, confidence interval; ACA, anticentromere antibodies; +, positivity; BP, blood pressure; VCAM-1, vascular cell adhesion molecule 1; ICAM-1, intercellular adhesion molecule 1; eGFR, estimated glomerular filtration rate, based on cystatin C measurements.

Nordin et al. Arthritis Research & Therapy 2013 15:R87   doi:10.1186/ar4267

Open Data