Table 3

Variables associated with ischemic arterial events in systemic sclerosis patients after age adjustment.

Any event (n = 20)

IHD (n = 13)

IPVD (n = 9)


Odds ratio (95% CI)

P value

Odds ratio (95% CI)

P value

Odds ratio (95% CI)

P value


Age

1.10 (1.05-1.17)

<0.0001

1.06 (1.01-1.13)

0.02

1.13 (1.05-1.26)

0.0005


Associations after adjustment for age


Kidney disease

8.8 (1.5-55.8)

0.01

6.6 (1.12-36.15)

0.04

ND

0.3

Skin score

1.13 (1.03-1.24)

0.008

1.07 (0.97-1.18)

0.1

1.16 (1.02-1.32)

0.02

Disease severity

1.29 (1.05-1.62)

0.02

1.11 (0.88-1.39)

0.4

1.15 (0.85-1.55)

0.3

ACA+

3.61 (1.21-11.3)

0.02

1.9 (0.55-6.45)

0.2

6.8 (1.37-45.3)

0.02

ATA+

0.18 (0.01-1.01)

0.05

0.00003 (0-0.6)

0.01

0.83 (0.04-5.67)

0.9

VCAM-1

5.30 (0.51-62.1)

0.2

27.3 (2.52-427. 4)

0.005

0.37 (0.02-5.46)

0.2

VEGF

0.68 (0.24-1.84)

0.4

0.29 (0.09-0.93)

0.03

0.52 (0.12-2.33)

0.4

eGFR

0.26 (0.10-0.62)

0.003

0.32 (0.12-0.81)

0.02

0.57 (0.15-3.65)

0.5


IHD, ischemic heart disease; IPVD, ischemic peripheral vascular disease; CI, confidence interval; ACA, anticentromere antibody; +, positivity; ATA, antitopoisomerase 1 antibody; VCAM-1, vascular cell adhesion molecule 1; VEGF, vascular endothelial growth factor; eGFR, estimated glomerular filtration rate, based on cystatin C measurements.

Nordin et al. Arthritis Research & Therapy 2013 15:R87   doi:10.1186/ar4267

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