Table 1

Characteristics of systemic sclerosis patients and controls at inclusion.

Patients (n = 111)

Controls (n = 105)

P value


Age, years

61.8 ± 12.5

61.5 ± 12.3

ns

Gender female % (n)

81 (90)

86 (90)

ns

Disease characteristics

Disease duration (years)

9.4 (5.6-17.4)

-

-

Diffuse cutaneous % (n)

Limited cutaneous % (n)

22 (24)

78 (87)

-

-

-

Pulmonary fibrosis % (n)

46 (51)

-

-

Suspected pulmonary hypertension % (n)

15 (17)

0

-

Raynaud % (n)

95 (105)

11 (12)

-

Digital ulcers ever % (n)

39 (43)

0

-

Calcinosis % (n)

27 (30)

0

-

Myositis % (n)

9 (10)

0

-

Arthritis % (n)

29 (32)

4 (4)

-

Kidney involvement % (n)

7 (8)

0

-

Skin score

6 (3-10)

0

-

Disease activity

0.5 (0-2)

-

-

Disease severity

5 (3-6)

-

-

Autoantibodies

Anticentromere (ACA) % (n)

Antitopoisomerase 1 (ATA) % (n)

Antinuclear (ANA) neg % (n)

32 (35)

23 (25)

7 (8)

-

-

-

Traditional cardiovascular risk factors

Body mass index (kg/m2)

24.2 ± 3.80

26.0 ± 3.7

0.0005

Waist-hip ratio

0.83 ± 0.09

0.84 ± 0.08

ns

Ever smoked % (n)

Current smoker % (n)

53 (59)

11 (12)

44 (46)

7 (7)

ns

ns

Systolic BP (mmHg)

Diastolic BP (mmHg)

Hypertension % (n)

123.18 ± 17.94

71.63 ± 10.65

30 (33)

124.09 ± 18.59

74.5 ± 9.49

20 (21)

ns

0.04

ns

P-glucose (mmol/l)

Diabetes % (n)

5.45 ± 1.17

6 (7)

5.43 ± 1.34

7 (7)

ns

ns

Cholesterol (mmol/l)

LDL (mmol/l)

HDL (mmol/l)

Triglycerides (mmol/l)

5.20 ± 1.04

3.32 ± 0.93

1.3 (1.0-1.5)

0.99 (0.76-1.5)

5.24 ± 1.15

3.37 ± 0.91

1.4 (1.2-1.7)

0.93 (0.67-1.3)

ns

ns

ns (0.09)

0.03

Inflammatory biomarkers

hsCRP (mg/l)

2.2 (1.0-4.3)

1.75 (0.76-3.2)

0.05

Orosomucoid (g/l)

0.86 ± 0.23

0.77 ± 0.17

0.0009

Alpha1antitrypsine (g/l)

1.5 (1.4-1.6)

1.4 (1.2-1.5)

<0.0001

Fibrinogen (g/l)

3.77 (3.3-4.34)

3.53 (2.80-4.25)

0.03

Sedimentation rate (mm)

Interleukin-6 (pg/ml)

14 (9-26)

29.9 (21.4-40.9)

10 (7-16.5)

27.1 (21.2-32.5)

0.002

ns (0.08)

Endothelial biomarkers

VCAM-1 (ng/l)

698 (546-807)

531 (431-719)

<0.0001

ICAM-1 (ng/l)

376 (314-472)

330 (254-450)

0.002

VEGF (pg/ml)

182 (143-258)

156 (103-239)

0.009

vWF (IU/ml)

1.25 (0.90-1.70)

0.85 (0.58-1.36)

<0.0001

Renal function

eGFR (mL/min/1.73 m2)

74 (50-116)

104 (89-126)

0.01


Distributions are given as % (n), median (interquartile range) or mean ± standard deviation. BP, blood pressure; LDL, low-density lipoprotein; HDL, high-density lipoprotein; hsCRP, high-sensitivity C reactive protein; VCAM-1, vascular cell adhesion molecule 1; ICAM-1, intercellular adhesion molecule 1; VEGF, vascular endothelial growth factor; vWF, von Willebrand factor; eGFR, estimated glomerular filtration rate, based on cystatin C measurements.

Nordin et al. Arthritis Research & Therapy 2013 15:R87   doi:10.1186/ar4267

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