Table 4

Odds ratios for radiographic progression when combining high and low level of C1M and CRP

C1M/CRP

High/High vs. Low/Low

High/Low vs. Low/Low

Low/High vs. Low/Low

Only C1M


JSN

OR

3.61

2.37

1.95

3.15

95% CI

1.62 to 8.01

0.59 to 9.44

0.39 to 9.77

1.50 to 6.58

P

0.0018

0.22

0.42

0.0023

mTSS

OR

3.55

1.79

1.94

2.94

95% CI

1.97 to 6.41

0.60 to 5.33

0.58 to 6.49

1.71 to 5.05

P

<0.0001

0.30

0.28

0.0001


The high and low levels of the biomarkers were based on the median value of all patients at baseline. C1M, Type I collagen degraded by MMPs; CI, confidence interval; CRP- C-reactive protein; JSN, joint space narrowing; mTSS, modified total Sharp score; OR, odds ratio

Siebuhr et al. Arthritis Research & Therapy 2013 15:R86   doi:10.1186/ar4266

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