Table 3

Multivariate linear regression analysis of patients in the PBO group, at 24 and 52 weeks.

Δ24 weeks

Δ52 weeks


JSN

β

P

R2

n

β

P

R2

n


C1M

0.34

0.013

0.04

153

1.38

0.0015

0.11

85

C1M adjusted for CRP

0.74

0.0013

0.06

153

3.91

<0.0001

0.27

85

C1M adjusted for CRP, age, BMI and disease duration

0.69

0.0022

0.11

151

3.60

<0.0001

0.30

83

C1M adjusted for CRP, age, BMI, disease duration and baseline JSN

0.68

0.0029

0.11

151

3.55

<0.0001

0.31

83

mTSS


C1M

1.13

0.0035

0.05

153

3.40

0.0001

0.17

85

C1M adjusted for CRP

1.17

0.07

0.04

153

7.13

<0.0001

0.25

85

C1M adjusted for CRP, age, BMI and disease duration

0.98

0.11

0.14

151

6.12

<0.0001

0.32

83

C1M adjusted for CRP, age, BMI, disease duration and baseline mTSS

0.95

0.13

0.14

151

6.04

<0.0001

0.32

83

ERN


C1M

0.79

0.009

0.038

153

2.01

0.0002

0.15

85

C1M adjusted for CRP

0.43

0.39

0.037

153

3.22

0.0006

0.17

85

C1M adjusted for CRP, age, BMI and disease duration

0.29

0.56

0.12

151

2.52

0.0055

0.25

83

C1M adjusted for CRP, age, BMI, disease duration and baseline ERN

0.26

0.59

0.12

151

2.47

0.0066

0.25

83


BMI, Body mass index; C1M, Type I collagen degraded by MMPs; CRP- C-reactive protein; ERN, erosion score; JSN, joint space narrowing; mTSS, modified total Sharp score. The regression coefficient, β, P-value and R2 are given. Data were log-transformed before analysis.

Siebuhr et al. Arthritis Research & Therapy 2013 15:R86   doi:10.1186/ar4266

Open Data