Inhibitory effect of double-antiangiogenic protein on bone destruction in collagen-induced arthritis. (A) Representative radiographs of hind paws. Note the severe bone erosions and joint damage (arrows), mild to moderate erosions (arrowheads) and periarticular osteopenia (asterisks). (B) Quantitative analysis of bone destruction. DAAP: Double-antiangiogenic protein; PBS: Phosphate-buffered saline; PCR: polymerase chain reaction; Tie2: Tyrosine kinase with immunoglobulin and epidermal growth factor homology domain 2; VEGF: Vascular endothelial growth factor. Values are mean ± SE, n = 20 for each group. *P < 0.05, **P < 0.01.
Hah et al. Arthritis Research & Therapy 2013 15:R85 doi:10.1186/ar4265