Preventive effect of double-antiangiogenic protein on collagen-induced arthritis. (A) Representative photographs showing the gross features of mice hind paws at day 40. Collagen-induced arthritis (CIA) mice were given intraperitoneal injections of phosphate-buffered saline (PBS), dimeric Fc (Fc), vascular endothelial growth factor (VEGF)-Trap, tyrosine kinase with immunoglobulin and epidermal growth factor homology domain 2 (Tie2)-Fc or double-antiangiogenic protein (DAAP) (25 mg/kg twice weekly, n = 10 for each group) from days 21 to 40. (B) Incidence of arthritis. (C) Arthritis scores. (D) Ankle thickness. Values are mean ± SE, n = 10 mice for each group. *P < 0.05, **P < 0.01.
Hah et al. Arthritis Research & Therapy 2013 15:R85 doi:10.1186/ar4265