Table 3

Parameters associated with decreased ability to degrade NETs

approximately 60 days before

Simultaneously

approximately 60 days after


Clinical

Proteinuria

Proteinuria

Proteinuria

manifestations

Pyuria

Pyuria

Cellular casts

Alopecia

Fever

Laboratory

Anti-DNA

Anti-DNA

Anti-DNA

variables

Anti-Histones

Anti-Histones

Leukopenia

Anti-Cardiolipin

Anti-Cardiolipin

Elevated CRP

Leukopenia

Low C3

Low C1q, C3 and C4

Medications

No HCa

No HCa

No HCa

Immunosuppressants

Immunosuppressants


Manifestations that occur significantly more frequently than expected, before, simultaneously or after the time point with decreased ability to degrade neutrophil extracellular traps (NETs).

aHC, hydroxychloroquine

Leffler et al. Arthritis Research & Therapy 2013 15:R84   doi:10.1186/ar4264

Open Data