Table 3

Improved aerobic capacity and endurance performance after 12 weeks of endurance exercise in myositis patients.

Before

Mean ± SD

After

Mean ± SD

Paired t-test


Exercise group (EG)


Endurance cycling test (n = 9)

Time to exhaustion (minutes)

15.4 + 5.1

33.7 + 13.3

P <0.01

Lactate (mM)

10.3 ± 2.5

6.5 ± 1.8

P <0.01

Percentage maximum heart rate

88 ± 8

88 ± 5

n.s.

Borg rating (6 to 20):

   Peripheral exertion

19 ± 1

17 ± 2

n.s.

   Central exertion

19 ± 1

17 ± 2

n.s.

VO2 max test (n = 7)

VO2 max (l min-1)

1.63 ± 0.30

1.91 ± 0.30

P <0.01

Power at VO2 max (W)

119 ± 25

138 ± 26

P <0.001

Mitochondrial enzyme activities (n = 3)

Citrate synthase

(μmol (g dw-1) min-1)

42.9 ± 2.0

76.8 ± 1.4

P <0.001

β-hydroxyacyl-CoA dehydrogenase

(β-HAD; μmol (g dw-1) min-1)

33.5 ± 6.5

50.1 ± 1.9

P <0.05


Control group (CG)


Endurance cycling test (n = 6)

Time to exhaustion (minutes)

13.7 ± 4.5

14.5 ± 4.8

n.s.

Lactate (mM)

9.9 ± 3.1

11.3 ± 3.5

n.s.

Percentage maximum heart rate

97 ± 2

95 ± 3

n.s.

Borg rating (6 to 20):

   Peripheral exertion

18 ± 2

18 ± 3

n.s.

   Central exertion

17 ± 2

17 ± 2

n.s.

VO2 max test (n = 5)

VO2 max (l min-1)

1.46 ± 0.30

1.32 ± 0.21

P <0.05

Power at VO2 max (W)

110 ± 16

102 ± 18

n.s.

Mitochondrial enzyme activities (n = 5)

Citrate synthase

(μmol (g dw-1) min-1)

52.8 ± 7.3

50.3 ± 13.0

n.s.

β-hydroxyacyl-CoA dehydrogenase

(β-HAD; μmol (g dw-1) min-1)

43.8 ± 10.1

36.7 ± 10.5

n.s.


n.s., Non-significant; VO2 max, maximal oxygen uptake; endurance cycling test, time cycling to exhaustion performed with a constant power, which in each individual was set to requiring 65% of baseline VO2 max; Borg rating, rating of exertion at end of VO2 max test and at the end of the endurance cycling test; Lactate, concentration of lactate measured in muscle vastus lateralis with microdialysis directly after the endurance cycling test.

Alemo Munters et al. Arthritis Research & Therapy 2013 15:R83   doi:10.1186/ar4263

Open Data