Table 1

Clinical characteristics of 121 patients with systemic sclerosis (SSc) according to the presence or absence of anti-centromere-associated protein antibodies (ACA)

Variable

All patients

ACA-positive (n = 75)

ACA-negative (n = 46)

P-value


Female, n (%)

113 (93.4)

71 (94.7)

42 (91.3)

0.470a

Age at diagnosis, years

38.8 (14.3)

39.3 (13.7)

37.8 (15.5)

0.530b

Disease duration, years

17.1 (10.3)

18.4 (10.6)

14.7 (9.4)

0.050b

Limited disease, n (%)

94 (77.7)

70 (93.3)

24 (52.2)

<0.0001 a

mRss

5.70 (7.00)

3.90 (6.40)

9.00 (7.10)

<0.0001 b

FVC, % of predicted

105.60 (20.20)

107.40 (19.10)

84.30 (22.20)

0.014b

DLCO, % of predicted

73.10 (23.80)

76.60 (25.00)

64.10 (17.80)

0.017b

sPAP, mm Hg

28.10 (10.60)

27.70 (11.60)

28.80 (8.80)

0.058b

ILD, n (%)

24 (27.6)

13 (18.0)

36 (78.6)

<0.0001a

PAH, n (%)

16 (13.2)

8 (10.7)

8 (17.4)

0.289a

Disease severity scale

   Total score

5.89 (3.46)

5.17 (2.80)

7.20 (4.12)

0.009b

   General

0.50 (0.80)

0.44 (0.70)

0.60 (0.93)

0.484b

   Peripheral vascular

1.52 (0.71)

1.46 (0.68)

1.61 (0.76)

0.212b

   Skin

0.83 (0.65)

0.66 (0.64)

1.14 (0.56)

<0.0001b

   Joint/tendon

0.47 (1.00)

0.26 (0.64)

0.85 (1.35)

0.012b

   Muscle

0.16 (0.50)

0.10 (0.42)

0.26 (0.62)

0.090b

   Gastrointestinal tract

0.83 (0.70)

0.77 (0.66)

0.94 (0.72)

0.200b

   Lung

1.34 (1.11)

1.22 (1.18)

1.54 (0.96)

0.111b

   Heart

0.24 (0.50)

0.24 (0.42)

0.25 (0.63)

0.514b

   Kidney

0.05 (0.41)

0.0 (0.0)

0.14 (0.68)

0.058b

Disease activity index

1.52 (1.68)

1.26 (1.31)

1.98 (2.14)

0.128b


Values are presented as mean (SD) unless otherwise indicated. aChi-squared test; bMann-Whitney U-test. mRss, modified Rodnan skin score; FVC, forced vital capacity; DLCO, diffusing lung capacity for carbon monoxide; sPAP, systolic pulmonary arterial pressure; PAH, pulmonary arterial hypertension (sPAP >35 mm Hg); ILD, interstitial lung disease.

Perosa et al. Arthritis Research & Therapy 2013 15:R72   doi:10.1186/ar4249

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