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Open Access Highly Accessed Research article

Epistasis with HLA DR3 implicates the P2X7 receptor in the pathogenesis of primary Sjögren's syndrome

Susan Lester1, Leanne Stokes23, Kristen K Skarratt2, Ben J Gu24, Kathy L Sivils5, Christopher J Lessard5, James S Wiley24 and Maureen Rischmueller16*

Author Affiliations

1 Department of Rheumatology, The Queen Elizabeth Hospital, Woodville South, South Australia, Australia

2 Sydney Medical School Nepean, University of Sydney, Nepean Hospital, Penrith, NSW, Australia

3 Health Innovations Research Institute, School of Medical Sciences, RMIT University, Bundoora, Victoria, Australia

4 Florey Neuroscience Institutes, University of Melbourne, Parkville, Victoria, Australia

5 Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA

6 Discipline of Medicine, University of Adelaide, South Australia, Australia

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Arthritis Research & Therapy 2013, 15:R71  doi:10.1186/ar4248

Published: 2 June 2013

Additional files

Additional file 1:

Table S1 showing custom Taqman genotyping primers and probes. Table S2 showing P2RX7 minor allele frequency in pSS patients (cohort 1, n = 114) and normal subjects (n = 136). Table S3 showing Genotyping results for P2RX7 A1405G for seropositive pSS, seronegative pSS and control subjects in cohort 1 and cohort 2.

Format: DOCX Size: 20KB Download file

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