Networks derived from Ingenuity Pathway Analysis software of children who achieved CRM status using MTX + Et compared with healthy controls. Network analysis in PBMC is shown in (A) and analysis in granulocytes is shown in (B). Note prominence of TNFA as a hub in these networks. Genes shown in red show higher expression in patients compared with controls, and those shown in green show lower expression..CRM, clinical remission on medication; ET, etanercept; MTX, methotrexate; PBMC, peripheral blood mononuclear cells.
Jiang et al. Arthritis Research & Therapy 2013 15:R100 doi:10.1186/ar4280