Table 2

Comparison of clinical manifestations in childhood-onset SLE and adult-onset SLE

Clinical manifestations

Odds ratio

95% confidence interval

I2 (%)a


More common in childhood-onset SLE

   Fever

1.48

1.24 to 1.76

0

   Thrombocytopenia

1.30

1.10 to 1.55

0

   Ulcers/mucocutaneous

1.35

1.13 to 1.61

0

   Urinary cellular casts

2.35

1.68 to 3.29

0

   Seizures

2.32

1.65 to 3.25

16

   Hemolytic anemia

1.90

1.44 to 2.52

17

   Combined IgG and IgM aCL

1.66

1.20 to 2.28

41

More common in adult-onset SLE

   Sicca

0.42

0.27 to 0.64

0

   Pleuritis

0.69

0.54 to 0.88

0

   Rheumatoid factor

0.53

0.32 to 0.87

0


aCL, anti-cardiolipin antibody; SLE, systemic lupus erythematosus. aI2 statistic was used to examine the between-study heterogeneity. Only disease features with I2 <50% were included in the table.

Mina and Brunner Arthritis Research & Therapy 2013 15:218   doi:10.1186/ar4256