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Highly Accessed Review

Update on differences between childhood-onset and adult-onset systemic lupus erythematosus

Rina Mina and Hermine I Brunner*

Author Affiliations

Division of Rheumatology, Cincinnati Children's Hospital Medical Center, University of Cincinnati, 3333 Burnet Avenue, MC 4010, Cincinnati, OH 45229, USA

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Arthritis Research & Therapy 2013, 15:218  doi:10.1186/ar4256

Published: 21 August 2013

Abstract

Systemic lupus erythematosus (SLE) is a complex autoimmune disease and occurs worldwide in both children and adults. The estimated annual incidence among children is 2.22/100,000 and among adults is 23.2/100,000 in the United States. There is increasing understanding about differences in disease manifestations, medication use, and disease severity between those with childhood-onset SLE as compared with adult-onset SLE. Children have a more fulminant disease onset and course than adults with SLE, resulting in two to three times higher mortality. In future years, we anticipate more insight into the genetics between childhood-onset SLE and adult-onset SLE to help delineate the best therapies for both subsets of patients.

Keywords:
childhood-onset systemic lupus erythematosus; systemic lupus erythematosus; children; lupus; adults; adolescents