Update on differences between childhood-onset and adult-onset systemic lupus erythematosus
Division of Rheumatology, Cincinnati Children's Hospital Medical Center, University of Cincinnati, 3333 Burnet Avenue, MC 4010, Cincinnati, OH 45229, USA
Arthritis Research & Therapy 2013, 15:218 doi:10.1186/ar4256Published: 21 August 2013
Systemic lupus erythematosus (SLE) is a complex autoimmune disease and occurs worldwide in both children and adults. The estimated annual incidence among children is 2.22/100,000 and among adults is 23.2/100,000 in the United States. There is increasing understanding about differences in disease manifestations, medication use, and disease severity between those with childhood-onset SLE as compared with adult-onset SLE. Children have a more fulminant disease onset and course than adults with SLE, resulting in two to three times higher mortality. In future years, we anticipate more insight into the genetics between childhood-onset SLE and adult-onset SLE to help delineate the best therapies for both subsets of patients.